NAPRALIEF® GASTRO-RESISTANT TABLETS
Prescription Strength Pain Relief
FOR MUSCLE, JOINT AND BACK PAIN
Choose Napralief®
Long-LASTIng pain relief tablets
When pain lasts a long time, relief needs to last longer.
Napralief provides pain relief for up to 12 hours, for relief from muscle, joint and back pain
Like all medicines, naproxen can cause side effects, although not everyone gets them. Always read the leaflet and follow your pharmacist’s advice.
PRESCRIPTION-STRENGTH PAIN RELIEF
For muscle, joint and back pain
FIGHTS INFLAMMATION
Designed to both relieve pain and reduce inflammation in the body.
LONG-LASTING
Provides up to 12 hours of pain relief.
Specifically for:‖
Muscle Pain
Joint Pain
Back Pain
Period Pain
Sprains & Strains
‖Napralief® Gastro-resistant Tablets are indicated in adults aged 18–50 years for the short-term relief of muscle or joint pain (such as sprains and strains, inflammation caused by sporting injuries, lower back pain, neck pain, or pain in the wrists or feet) and period pain.
HOW IT ALL WORKS
HOW DOES NAPRALIEF® WORK?
The active ingredient in Napralief® is naproxen, a nonsteroidal anti-inflammatory drug (NSAID) used for many years in the treatment of mild-to-moderate pain.1,2,4
Since Naproxen is broken down in the body more slowly than ibuprofen, it can have a longer lasting effect on pain relief - making all day pain relief a possibility.1,3,4,5,6
DID YOU KNOW?
Naproxen is broken down in the body more slowly than ibuprofen!1,3,4,6
The analogy below shows how Napralief works to reduce pain and inflammation:
Imagine your body is like a forest, and pain and inflammation are like a wildfire that breaks out when something goes wrong – like an injury or infection.
When tissue is damaged, your body sends out chemical signals (like prostaglandins7), that cause swelling, redness, heat, and pain – just like a fire spreading through dry brush.
NSAIDs (like Napralief®) are like firefighters who rush in to help stop the fire (pain) at its source. They do this by blocking the enzymes that produce the prostaglandins.1,8
This helps reduce the flames (inflammation) and help put out the fire (pain relief).
EVERYTHING YOU NEED TO KNOW
Frequently Asked Questions
Find answers to commonly asked questions and if you still have questions, ask your pharmacist or your doctor for more information
Some people experiencing muscle, joint or period pain may look for a long lasting pain relief option.
Napralief contains Naproxen, a long-acting pain reliever that has been shown to provide pain relief for up to 12 hours.5,9,10
– Follow the dosing instructions in the leaflet and consult your pharmacist or doctor if you’re not sure
– Napralief® is taken as tablets for swallowing. Swallow the tablets whole with a little water, with or after food
– Don’t break, crush or chew the tablets
On the first day:
1. Take 2 tablets
2. Wait 6 to 8 hours
3. If the pain is still present, you can take 1 more tablet
On following days:
1. If the pain is still present, you can take 1 tablet every 6 to 8 hours
Do not take more than 3 tablets a day.
Napralief® is only intended for short-term use. Do no use for more than 3 days. If your pain persists beyond 3 days or worsens despite use of Napralief®, consult with your doctor immediately.
Napralief® is suitable for adults aged 18–50 years.
Always follow your pharmacist’s or doctor’s instructions.
Napralief® Gastro-resistant Tablets are indicated in adults aged 18–50 years for the short-term relief of muscle or joint pain (such as sprains and strains, inflammation caused by sporting injuries, lower back pain, neck pain, or pain in the wrists or feet) and period pain.
It is not advisable to drink alcohol while taking medication.
Drinking too much alcohol may irritate your stomach and negatively impact your health in other ways. Regularly drinking more than 14 units of alcohol a week risks damaging your health.10
Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. This includes medicines that you buy without a prescription and herbal medicines. Including other pain killers, like aspirin/acetylsalicylic acid, ibuprofen, diclofenac and paracetamol
Refer to the patient information leaflet for more information11
For over a century, We’ve been experts in everyday medicine – but it’s your goals that lead the way. From the makers of Solpadeine® and SolpaOne®, we’re behind you for wherever your journey takes you.
Napralief 250 mg Gastro-resistant Tablets contain naproxen. For the short-term relief of muscle or joint pain and period pain. Always read the leaflet.
- Brutzkus JC, et al. Naproxen. Available at: https://www.ncbi.nlm.nih.gov/books/NBK525965/. Accessed March 2026.
- LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Naproxen. Available from: https://www.ncbi.nlm.nih.gov/books/NBK548159/. Accessed September 2026.
- Cooper SA, et al. Curr Med Res Opin. 2019;35(12):2149-2158.
- Daniels SE, et al. Curr Med Res Opin. 2019;35(12):2139-2148.
- Weisman SM, J Pharm Pharm Sci. 2024 Feb 7;27:12384.
- Bushra R, Aslam N. Oman Med J. 2010;25(3):155–1661.
- Soliman AM, Barreda DR. Int J Mol Sci. 2022;24(1):641.
- Gunaydin C, Bilge SS. Eurasian J Med. 2018;50(2):116-121.
- NHS. Ibuprofen for adults. Available at: https://www.nhs.uk/medicines/ibuprofen-for-adults/. Accessed September 2026.
- NHS. Paracetamol for adults: painkiller for pain and high temperature. Available at: https://www.nhs.uk/medicines/paracetamol-for-adults/. Accessed September 2026.
- PIL
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